CYGB — Cytoglobin
CYGB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYGB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CYGB+ Quiescent Fibroblast Housekeeping | CCND1, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1, PDK4 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CD79B, DNTT, EBF1, FRMD4A, IL2RA, IL7R +4 more | |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | BGN, LAMC3, LGALS3BP, LPL, MMP11, NREP, PCDH18, PLOD2 +2 more | View in SCUBA |
About the gene
| Synonyms | HGB, STAP |
|---|---|
| Chromosome | 17: 76527356-76551175 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Molecular function | Oxidoreductase |
Function
Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.