CD79B — CD79b molecule
CD79B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD79B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B-cell identity B cell maturation | ALOX5AP, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SEC62, SIAH2 +7 more | View in SCUBA |
| CD4⁺ T cells | Regulatory T cell Immune regulation | ACTA2, APOLD1, ATP13A3, CARD16, CD27, DNAH8, FAM184A, HS3ST3B1 +7 more | View in SCUBA |
| Endothelial | Immune Cell Contamination Cell contamination | ANKRD65, CADM1, CLEC1A, IL3RA, JDP2, KAZN, MYH11, MYLK +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CYGB, DNTT, EBF1, FRMD4A, IL2RA, IL7R +4 more | |
| Monocytes | Non-classical Monocyte Innate immunity | CDH23, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2, NEURL1 +6 more | View in SCUBA |
About the gene
| Synonyms | B29, Ig-beta, IGB, Igbeta |
|---|---|
| Chromosome | 17: 63928738-63932336 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.