Pro-B Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes EBF1 (early B cell factor, master regulator of B lymphopoiesis), CD79A and CD79B (Igα/Igβ, essential B cell receptor signaling components), VPREB1 and VPREB3 (surrogate light chain components of the pre-B cell receptor), DNTT (terminal deoxynucleotidyl transferase, expressed in pro-B/pre-B cells undergoing VDJ recombination), IL7R (IL-7 receptor, critical for B lymphopoiesis), IL2RA (CD25, expressed during early B lymphocyte development), CYGB (cytoglobin, expressed in some progenitor states), UHRF1 (DNA methylation maintenance, active in proliferating progenitors), RETREG1 (reticulophagy, ER quality control). This is a tight early B-lineage progenitor signature: EBF1+DNTT+VPREB1/3+CD79A/B+IL7R defines the pro-B to pre-B cell transition. Very low mean expression (0.031) and 1.9% pct positive is consistent with a rare progenitor population within HPCs. As a neighbor of M51 (lymphoid TFs) and M4 (naive B cells), this module represents the earliest committed B cell progenitor stage in the developmental hierarchy. Concordant genes: EBF1, CD79A, CD79B, VPREB1, VPREB3, DNTT, IL7R, IL2RA, UHRF1.
Genes
ARPP21, CD79A, CD79B, CYGB, DNTT, EBF1, FRMD4A, IL2RA, IL7R, RETREG1, UHRF1, VPREB1, VPREB3
Most correlated modules
- Lymphoid Progenitor Commitment · correlation 0.61
- Lymphoid-Primed Progenitor · correlation 0.55
- Myeloid Commitment · correlation 0.55
- Naive B Cell · correlation 0.54
- Multipotent Progenitor Identity · correlation 0.54
- Lymphoid Progenitor TFs · correlation 0.52
- HOX HSC Program · correlation 0.51
- T/NK Cell Identity · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.