FRMD4A — FERM domain containing 4A
FRMD4A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRMD4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NFAT-cAMP Signaling Inflammatory | ACKR3, ADGRE2, ANKRD28, CHSY1, CREM, ELL2, GPCPD1, RCAN1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CD79B, CYGB, DNTT, EBF1, IL2RA, IL7R +4 more | |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | DAB2, ETV5, FOLR2, GPNMB, ITGB5, LGMN, LILRB5, LYVE1 +7 more | View in SCUBA |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, EBF1, FRY, ITGA7, LGALSL, LGI4, MCAM, MEF2C +6 more | View in SCUBA |
About the gene
| Synonyms | bA295P9.4, FLJ10210, FRMD4, KIAA1294 |
|---|---|
| Chromosome | 10: 13643706-14462142 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.