MGAT4B — Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
MGAT4B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGAT4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte Ion/Nutrient Transport Absorption | AKR1A1, AKR7A3, CALM1, CHP2, CLDN15, FCGRT, LGALS2, MPST +2 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
About the gene
| Synonyms | GnT-Ivb |
|---|---|
| Chromosome | 5: 179797597-179806952 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Prefers complex-type N-glycans over hybrid-types. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.