CLDN15 — Claudin 15
CLDN15 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLDN15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TRAIL-mediated Apoptosis Stress | ELOVL7, EVA1C, FGD4, ISCU, LMCD1, SELENOM, TIMMDC1, TMEM273 +2 more | View in SCUBA |
| Enterocytes | Enterocyte Ion/Nutrient Transport Absorption | AKR1A1, AKR7A3, CALM1, CHP2, FCGRT, LGALS2, MGAT4B, MPST +2 more | View in SCUBA |
About the gene
| Chromosome | 7: 101232092-101238820 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Transport |
Function
Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.