MPST — Mercaptopyruvate sulfurtransferase
MPST belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MPST's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CMBL, CTDSPL, DDB2, FLRT2, ITM2C +11 more | View in SCUBA |
| Enterocytes | Enterocyte Ion/Nutrient Transport Absorption | AKR1A1, AKR7A3, CALM1, CHP2, CLDN15, FCGRT, LGALS2, MGAT4B +2 more | View in SCUBA |
| Gamma-delta T cells | Basal Lipid Metabolism Housekeeping | ACOT7, ADCY3, AHCY, CLN6, DENND6B, FANCL, MGLL, NUDT8 +6 more | |
| Goblet cells | Mitochondrial Homeostasis Mitochondrial & OxPhos | BZW2, COX5A, PEBP1, PHB2, PPIA, PRDX2, SNRPE | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | BLVRB, HBQ1, HES6, MPC2, REXO2, SMIM10, TMEM14B, TMEM14C +2 more | |
| Innate lymphoid cells | Oxidative Phosphorylation Mitochondrial & OxPhos | APEX1, ATP5F1A, CCNC, COA3, DMAC1, ESD, HDAC2, HINT2 +15 more | View in SCUBA |
About the gene
| Synonyms | MST, TST2, TUM1 |
|---|---|
| Chromosome | 22: 37019635-37029821 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.