Enterocyte Ion/Nutrient Transport
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Absorptive enterocyte differentiation genes are prominent. These include FCGRT (FcRn IgG transport), SLC39A5 (zinc uptake), CLDN15 (paracellular Na+ channel), CHP2 (NHE regulator) and LGALS2. Alongside them are metabolic enzymes AKR1A1, AKR7A3, MPST and SUCLG1. Overall this is a mature absorptive enterocyte transport program.
Genes
AKR1A1, AKR7A3, CALM1, CHP2, CLDN15, FCGRT, LGALS2, MGAT4B, MPST, SLC39A5, SUCLG1
Most correlated modules
- Carbohydrate Digestion/Detox · correlation 0.93
- Xenobiotic Detoxification · correlation 0.88
- Gluconeogenesis/fructose metabolism · correlation 0.85
- Lipid/bile acid uptake · correlation 0.82
- PGC1A/ERRG metabolic program · correlation 0.79
- Respiratory Chain Subunits · correlation 0.77
- Oxidative Phosphorylation · correlation 0.76
- Mitochondrial Energy Metabolism · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.