MSRB1 — Methionine sulfoxide reductase B1
MSRB1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MSRB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Classical Monocyte Trafficking Migration & adhesion | ANXA6, CKAP4, EMB, F5, GCA, MAP2K6, MPP7, PADI4 +4 more | View in SCUBA |
About the gene
| Synonyms | SELENOR, SELENOX, SelR, SelX, SepR, SEPX1 |
|---|---|
| Chromosome | 16: 1938229-1943199 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Immunity, Innate immunity |
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.