F5 — Coagulation factor V
F5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
F5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell activation TCR/AP1/NFKb pathway | C16orf87, CAMK1, CBLB, CD4, CD7, CDK6, CIAO1, COPB2 +7 more | View in SCUBA |
| Monocytes | Classical Monocyte Trafficking Migration & adhesion | ANXA6, CKAP4, EMB, GCA, MAP2K6, MPP7, MSRB1, PADI4 +4 more | View in SCUBA |
| Neutrophils | Inflammasome Signaling Regulation Inflammatory | ADAM19, MAP2K6, NLRP12, PRKACA, RNF10, SLC37A3, TENM1 |
About the gene
| Chromosome | 1: 169511951-169586588 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Biological process | Blood coagulation, Hemostasis |
Function
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.