MTARC1 — Mitochondrial amidoxime reducing component 1
MTARC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTARC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Leukotriene-Alarmin Response Inflammatory | ALOX5AP, CDA, METTL9, PLBD1, QPCT, RFLNB, S100A12, TMEM38A | View in SCUBA |
About the gene
| Synonyms | FLJ22390, MARC1, MOSC1 |
|---|---|
| Chromosome | 1: 220786352-220819659 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.