QPCT — Glutaminyl-peptide cyclotransferase
QPCT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
QPCT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, EHD1, F3, LAMC1, LIPG, MED24, PLEKHO1 +7 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more | View in SCUBA |
| Monocytes | Leukotriene-Alarmin Response Inflammatory | ALOX5AP, CDA, METTL9, MTARC1, PLBD1, RFLNB, S100A12, TMEM38A | View in SCUBA |
| Neutrophils | Neutrophil Differentiation Developmental | ABTB1, FRAT2, GCA, ICAM3, MANSC1, MNDA, MSL3, NFE2 +2 more |
About the gene
| Synonyms | GCT, QC |
|---|---|
| Chromosome | 2: 37342827-37373322 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Acyltransferase, Transferase |
Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.