S100A12 — S100 calcium binding protein A12
S100A12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S100A12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Leukotriene-Alarmin Response Inflammatory | ALOX5AP, CDA, METTL9, MTARC1, PLBD1, QPCT, RFLNB, TMEM38A | View in SCUBA |
| Neutrophils | S100 Alarmin Response Inflammatory | CD177, H2AC6, METTL9, MS4A6A, RBP7, S100A4, S100A6, SH3BGRL3 |
About the gene
| Synonyms | CAAF1, CAGC, CGRP, ENRAGE, MRP6, p6 |
|---|---|
| Chromosome | 1: 153373711-153375621 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Fungicide |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.