Leukotriene-Alarmin Response
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
ALOX5AP (FLAP, 5-lipoxygenase activating protein) is essential for leukotriene biosynthesis and is a canonical myeloid inflammatory mediator. S100A12 is a potent alarmin (DAMP) released by neutrophils and monocytes during inflammation, activating RAGE. PLBD1 (lysosomal phospholipase) supports phagocytic/lysosomal activity. CDA (cytidine deaminase) is expressed in myeloid cells. MTARC1 (mitochondrial amidoxime reducing component) is involved in metabolic detoxification. Significantly increased in UC inflammation, decreased in remission. The leukotriene/alarmin axis defines this as an inflammatory lipid mediator program.
Genes
ALOX5AP, CDA, METTL9, MTARC1, PLBD1, QPCT, RFLNB, S100A12, TMEM38A
Most correlated modules
- Classical Monocyte Trafficking · correlation 0.86
- Classical Monocyte Activation · correlation 0.81
- Monocyte Innate Surveillance · correlation 0.78
- Myeloid Activation · correlation 0.78
- Pentose Phosphate Pathway · correlation 0.75
- p38 MAPK Signaling · correlation 0.73
- Granulocytic Differentiation · correlation 0.70
- Monocyte-DC Differentiation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.