PLBD1 — Phospholipase B domain containing 1
PLBD1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLBD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | TGF-beta Response ECM remodeling | C1orf21, CBR3, CNRIP1, DOK5, FREM1, GUSB, HTRA1, LRRN4CL +7 more | View in SCUBA |
| Goblet cells | Mature Colonocyte Function Epithelial development | ADD3, CERS6, CFTR, GAS6, LEFTY1, MAOA, NOX1, PDCD4 +2 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
| Monocytes | Leukotriene-Alarmin Response Inflammatory | ALOX5AP, CDA, METTL9, MTARC1, QPCT, RFLNB, S100A12, TMEM38A | View in SCUBA |
| Neutrophils | NET Priming State Netosis | ADD3, APMAP, ARG1, CCDC125, CCPG1, ITGAM, PADI4, PPP2R5A +1 more |
About the gene
| Synonyms | FLJ22662 |
|---|---|
| Chromosome | 12: 14503661-14567883 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.