METTL9 — Methyltransferase like 9
METTL9 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
METTL9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, CRELD2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3 +9 more | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more | |
| Goblet cells | Epithelial Maintenance Housekeeping | COX7A2L, DDAH2, IP6K2, LAPTM4A, MARCKS, MKRN1, RNF44 | View in SCUBA |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | Leukotriene-Alarmin Response Inflammatory | ALOX5AP, CDA, MTARC1, PLBD1, QPCT, RFLNB, S100A12, TMEM38A | View in SCUBA |
| Neutrophils | S100 Alarmin Response Inflammatory | CD177, H2AC6, MS4A6A, RBP7, S100A12, S100A4, S100A6, SH3BGRL3 |
About the gene
| Synonyms | DREV1 |
|---|---|
| Chromosome | 16: 21597218-21657471 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature. Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1- methylhistidine modification in cell.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.