NECTIN1 — Nectin cell adhesion molecule 1
NECTIN1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NECTIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Secretory Lineage Specification Epithelial development | ANXA13, ATOH1, CA8, CBFA2T2, DLL1, DYRK4, FOXA2, FRA10AC1 +12 more | View in SCUBA |
About the gene
| Synonyms | CD111, CLPED1, ED4, HIgR, HVEC, Nectin-1, OFC7, PRR, PRR1, PVRL1, PVRR1, SK-12 |
|---|---|
| Chromosome | 11: 119623408-119729200 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Cell adhesion, Host-virus interaction |
Function
Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans- dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth- promoting activity (By similarity). Promotes formation of checkerboard- like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity). (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.