OR51E2 — Olfactory receptor family 51 subfamily E member 2
OR51E2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OR51E2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC neuromuscular junction Gut motility | ATP1A2, ATRNL1, CASQ2, COL19A1, CTNNA3, FAM83D, KCNIP4, LRRC7 +6 more | View in SCUBA |
| Smooth muscle cells | Arteriolar Mural Cells Development | ESAM, FOXS1, GJA4, LINGO1, NDUFA4L2, NGF, OR51E1, PDGFA +3 more | View in SCUBA |
About the gene
| Synonyms | PSGR |
|---|---|
| Chromosome | 11: 4680171-4697854 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Olfaction, Sensory transduction |
Function
Olfactory receptor. Activated by the odorant, beta-ionone, a synthetic terpenoid. The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1. Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis. Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells. Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation. Activated by L-lactate in glomus cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.