LINGO1 — Leucine rich repeat and Ig domain containing 1
LINGO1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LINGO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Pericyte Vascular Tone Developmental | ADAP2, CHCHD10, CSPG4, FOXS1, MCAM, MFGE8, PGF, PTGIR +3 more | View in SCUBA |
| Smooth muscle cells | Arteriolar Mural Cells Development | ESAM, FOXS1, GJA4, NDUFA4L2, NGF, OR51E1, OR51E2, PDGFA +3 more | View in SCUBA |
About the gene
| Synonyms | FLJ14594, LERN1, LRRN6A |
|---|---|
| Chromosome | 15: 77613027-77820900 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.