PDGFA — Platelet derived growth factor subunit A
PDGFA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDGFA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF activation survival Immune regulation | BCL2L1, CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B +12 more | View in SCUBA |
| Glial cells | TGF-beta ECM Remodeling ECM remodeling | GALNT2, HCFC1R1, ITGB8, LOXL3, RCAN1, S1PR3, SPRY1 | View in SCUBA |
| Goblet cells | Notch Secretory Specification Epithelial development | EDN1, EREG, FKBP1A, GPRC5C, HES4, HES5, MYC, NOTCH2 +4 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | BATF3, CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, RHOBTB3, RHOQ +3 more | View in SCUBA |
| Smooth muscle cells | Arteriolar Mural Cells Development | ESAM, FOXS1, GJA4, LINGO1, NDUFA4L2, NGF, OR51E1, OR51E2 +3 more | View in SCUBA |
About the gene
| Synonyms | PDGF-A, PDGF1 |
|---|---|
| Chromosome | 7: 497258-520296 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Growth factor, Mitogen |
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.