Arteriolar Mural Cells
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
NDUFA4L2, GJA4 (connexin 37, arterial/arteriolar), FOXS1, ESAM, OR51E1/OR51E2 and HIGD1B-type genes define arteriolar mural cells/precapillary pericytes, while PGF, PDGFA, SLIT3 and NGF are angiocrine/vessel-patterning ligands secreted by this population. The combination indicates an arteriolar mural cell state engaged in vascular signalling; consistent with the neighboring pericyte modules M7 and M31 that carry distinct capillary pericyte markers.
Genes
ESAM, FOXS1, GJA4, LINGO1, NDUFA4L2, NGF, OR51E1, OR51E2, PDGFA, PGF, PTK2, SLIT3
Most correlated modules
- Mural/Pericyte Identity · correlation 0.89
- Vasoconstrictor Signaling · correlation 0.88
- Capillary Pericyte · correlation 0.81
- Pericyte Basement Membrane · correlation 0.81
- Wnt-Notch Modulation · correlation 0.80
- Notch-TGFbeta Signaling · correlation 0.79
- Vascular Tone Signaling · correlation 0.75
- FOXC-PRDM16 Program · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.