PATZ1 — POZ/BTB and AT hook containing zinc finger 1
PATZ1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PATZ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Survival Signaling Epithelial development | ABCC4, BCL2, CAMK1D, CNTRL, DEPTOR, FOXP2, G2E3, GMNN +14 more | View in SCUBA |
About the gene
| Synonyms | dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG |
|---|---|
| Chromosome | 22: 31325804-31346346 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. (Microbial infection) Plays a positive role in viral cDNA synthesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.