PREX2 — Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
PREX2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PREX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hippo-YAP Cytoskeletal Cytoskeletal | CSRP1, EHD2, FDPS, FLNA, FLNB, MANSC1, MAP1B, MSRB3 +4 more | View in SCUBA |
| Fibroblasts | Telocyte Identity Program Developmental | ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5 +10 more | View in SCUBA |
About the gene
| Synonyms | DEP.2, DEPDC2, FLJ12987, P-REX2, PPP1R129 |
|---|---|
| Chromosome | 8: 67952046-68237032 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5- trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.