FLNB — Filamin B
FLNB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLNB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hippo-YAP Cytoskeletal Cytoskeletal | CSRP1, EHD2, FDPS, FLNA, MANSC1, MAP1B, MSRB3, MTCH1 +4 more | View in SCUBA |
| Pericytes | Arterial Identity TFs Developmental | EPHA4, GATA2, MAST4, MECOM, MTUS1, PALMD, PIK3C2B, SOX17 | View in SCUBA |
About the gene
| Synonyms | ABP-278, FH1, FLN1L, LRS1, TABP, TAP |
|---|---|
| Chromosome | 3: 58008398-58172251 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Actin-binding, Developmental protein |
| Biological process | Differentiation, Myogenesis |
Function
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.