Telocyte Identity Program
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
FOXF1 is a canonical transcription factor for intestinal subepithelial fibroblasts/telocytes and is essential for intestinal stromal identity. PTCH1 (Hedgehog pathway receptor) is a key mediator of fibroblast-epithelial crosstalk in the intestine. TBX3 and SALL1 are developmental transcription factors expressed in mesenchymal cells. LAMA4 and FBLN7 are ECM components of the stromal niche. ADGRL3 (latrophilin), PRKG1, and RCSD1 support a specialized mesenchymal identity. This module represents the core transcriptional identity of intestinal telocytes/subepithelial fibroblasts, driven by FOXF1 and Hedgehog signaling.
Genes
ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5, PREX2, PRKG1, PTCH1, RBPMS, RCSD1, RGS10, SALL1, STMN1, TBL1X, TBX3, TNIK
Most correlated modules
- Myofibroblast Subtype · correlation 0.92
- Caveolae Mechanosensing · correlation 0.90
- WNT-modulating Fibroblast · correlation 0.86
- Basement Membrane ECM · correlation 0.81
- Fibroblast Niche Identity · correlation 0.80
- Intestinal Fibroblast Identity · correlation 0.80
- Metabolic Homeostasis · correlation 0.79
- Thrombin Receptor Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.