Hippo-YAP Cytoskeletal
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
TEAD4 is the transcriptional effector of the Hippo/YAP pathway, a key mechanosensing and cytoskeletal regulator in endothelial cells. FLNA and FLNB encode filamins that crosslink actin and interact with YAP/TEAD signaling. PREX2 is a Rac1 GEF downstream of PI3K, regulating actin dynamics. CSRP1 is a LIM-domain actin-binding protein. MAP1B is a microtubule-associated protein. FDPS (farnesyl diphosphate synthase) in the mevalonate pathway produces isoprenoids required for Rho/Rac GTPase prenylation and membrane targeting. EHD2 regulates caveolae/endocytic recycling. MSRB3 (methionine sulfoxide reductase) is a redox enzyme. MTCH1 is a mitochondrial carrier. The module is significantly upregulated in IBD inflammation, consistent with Hippo/YAP-mediated endothelial cytoskeletal remodeling during vascular inflammation.
Genes
CSRP1, EHD2, FDPS, FLNA, FLNB, MANSC1, MAP1B, MSRB3, MTCH1, PLEKHB2, PREX2, TEAD4, TMEM50A
Most correlated modules
- Endothelial NO Activation · correlation 0.92
- Vascular Tone Regulation · correlation 0.88
- Oxidative Stress Response · correlation 0.86
- WAVE Complex Cytoskeleton · correlation 0.85
- Rho-Actin Remodeling · correlation 0.85
- ER Calcium Stress · correlation 0.81
- Endocytic Membrane Remodeling · correlation 0.78
- ER-Golgi Trafficking · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.