ADGRL3 — Adhesion G protein-coupled receptor L3
ADGRL3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Telocyte Identity Program Developmental | ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5, PREX2 +10 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | APOC1, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3, NPNT +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA0768, LEC3, LPHN3 |
|---|---|
| Chromosome | 4: 61200326-62078335 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors. ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context. Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient. Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of Schaffer- collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (By similarity). Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation (By similarity). Plays a role in the development of glutamatergic synapses in the cortex (By similarity). Important in determining the connectivity rates between the principal neurons in the cortex (By similarity). Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.