LAMA4 — Laminin subunit alpha 4
LAMA4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Fibroblasts | Telocyte Identity Program Developmental | ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, PDIA5, PREX2 +10 more | View in SCUBA |
| Lymphatic endothelial | Hippo-mTOR Quiescence endothelial development | BCAT1, FILIP1, FRMD6, KLHL3, NIBAN1, PRR5L, SCN9A | View in SCUBA |
| Pericytes | Basement Membrane Assembly ECM production | F2R, FARP1, ITGB1, JAK1, LAMC1, LIMS1, NID1, PELO +1 more | View in SCUBA |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL5A2, COL6A3, LAMB1, NEGR1, PARVA, PCDH7, RAB32 +4 more | View in SCUBA |
About the gene
| Synonyms | LAMA3 |
|---|---|
| Chromosome | 6: 112107931-112254939 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.