RNF13 — Ring finger protein 13
RNF13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Actin Cytoskeletal Scaffold Cytoskeletal | CCDC102B, CCND3, DAAM1, DPYSL3, EPB41L2, GOLM2, GPATCH2, KLHL4 +1 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 more | View in SCUBA |
About the gene
| Synonyms | RZF |
|---|---|
| Chromosome | 3: 149812770-149962139 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.