Actin Cytoskeletal Scaffold
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include EPB41L2 (band 4.1 protein, links cytoskeleton to membrane), DPYSL3 (CRMP3, microtubule-associated cytoskeletal), DAAM1 (formin, actin polymerization), PPFIBP1 (liprin-beta1, focal adhesion scaffold), KLHL4 (kelch-like, actin organization), CCDC102B (coiled-coil cytoskeletal). Multiple actin/cytoskeletal regulators dominate. GOLM2 (Golgi membrane protein) and RNF13 (ubiquitin ligase) are peripheral. CCND3 (cyclin D3) is a minor member. The module is primarily cytoskeletal scaffolding and actin organization.
Genes
CCDC102B, CCND3, DAAM1, DPYSL3, EPB41L2, GOLM2, GPATCH2, KLHL4, PPFIBP1, RNF13
Most correlated modules
- Lymphatic Valve Development · correlation 0.94
- Chromatin Remodeling · correlation 0.91
- Endosomal Vesicle Trafficking · correlation 0.91
- Hypoxia Response · correlation 0.90
- Lymphatic EC Identity · correlation 0.88
- Lipid Metabolic Regulation · correlation 0.88
- Lymphangiogenesis ECM · correlation 0.86
- Endothelial Receptor Signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.