RXFP1 — Relaxin family peptide receptor 1
RXFP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RXFP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent Arterial EC Endothelial cell development | ABCG2, ANKRD50, CAMTA1, CDH23, CTNNAL1, CYB5A, HLF, INMT +10 more | View in SCUBA |
| Hematopoietic progenitor cells | Early Myeloid Progenitor Myeloid development | ABCA13, ARID5B, CD34, GPRIN3, NCOA7, PRSS2, SETBP1 |
About the gene
| Synonyms | LGR7, RXFPR1 |
|---|---|
| Chromosome | 4: 158315311-158653372 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.