Early Myeloid Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CD34 is the canonical HSC/progenitor marker; SETBP1 is highly expressed in immature hematopoietic progenitors and implicated in myeloid progenitor self-renewal; ARID5B is a transcription factor important in early hematopoietic and lymphoid development; ABCA13 is expressed in granulocyte precursors; NCOA7 is a nuclear receptor coactivator active in early progenitors. This module captures an early/immature progenitor state with features of both stemness and early myeloid commitment, neighboring M29's multipotent progenitor module.
Genes
ABCA13, ARID5B, CD34, GPRIN3, NCOA7, PRSS2, RXFP1, SETBP1
Most correlated modules
- Lymphoid-Primed Progenitor · correlation 0.78
- Quiescent HSC State · correlation 0.78
- HOX HSC Program · correlation 0.75
- Multipotent Progenitor Identity · correlation 0.73
- Myeloid Commitment · correlation 0.63
- Megakaryocyte IFN-primed · correlation 0.63
- Lymphoid Progenitor TFs · correlation 0.61
- Naive B Cell · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.