SCUBA

NCOA7 — Nuclear receptor coactivator 7

NCOA7 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NCOA7's module in each cell type

Cell typeModuleShares the module with
EndothelialEndothelial Quiescence Identity
Endothelial cell development
CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7 +7 moreView in SCUBA
EnterocytesEpithelial junction adhesion
Migration & adhesion
ADGRG6, CEACAM6, CTNNB1, DSG2, KTN1, SAMD9L, SH3GLB1, TOP1 +2 moreView in SCUBA
FibroblastsNF-κB Stress Response
Inflammatory
EGR3, NAMPT, NFIL3, PHLDA1, PHLDA2, SAT1, SLC20A1, SOD2 +3 moreView in SCUBA
Goblet cellsEGF-Driven Wound Repair
Epithelial development
AREG, ARL14, C3orf52, CXCL8, F11R, HBEGF, RAP2B, RHPN2 +1 moreView in SCUBA
Hematopoietic progenitor cellsEarly Myeloid Progenitor
Myeloid development
ABCA13, ARID5B, CD34, GPRIN3, PRSS2, RXFP1, SETBP1
Innate lymphoid cellsCytokine-driven Activation
activation
BIRC3, CALR, CD69, DUSP5, GADD45G, ISG15, PPIF, RUNX3 +2 moreView in SCUBA
MacrophagesMyeloid Signaling Regulation
Innate immunity
ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 moreView in SCUBA
Mucosal-associated invariant T cellCircadian Transcriptional Regulation
DNA/chromatin regulation
ABCB1, ANKRD12, ATOSA, BMAL1, CEP250, GCC2, MIA3, MIER1 +2 more
PericytesNF-kB Chemokine Response
Inflammatory
CCL2, CCL8, CXCL1, CXCL2, PRDM1, SOD2, TNFAIP3View in SCUBA

About the gene

SynonymsdJ187J11.3, ERAP140, TLDC4
Chromosome6: 125781161-125932034
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins, Transporters
Molecular functionActivator
Biological processTranscription, Transcription regulation

Function

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.