CD34 — CD34 molecule
CD34 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD34's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Capillary Endothelial Identity Endothelial cell development | ATOH8, AVPR2, BTNL9, C1QTNF9, CD300LG, CNFN, FAM13C, IQCK +10 more | View in SCUBA |
| Fibroblasts | CD34+ Quiescent Fibroblast ECM production | ABLIM1, C1QTNF3, CILP, CLDN11, CPVL, FAIM2, FOLH1, GPC3 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Early Myeloid Progenitor Myeloid development | ABCA13, ARID5B, GPRIN3, NCOA7, PRSS2, RXFP1, SETBP1 | |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | A2M, CISD1, FAM89A, FHL3, FSCN1, GJC2, GRAP, HTRA1 +5 more | View in SCUBA |
About the gene
| Chromosome | 1: 207880972-207911402 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.