SDHB — Succinate dehydrogenase complex iron sulfur subunit B
SDHB belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SDHB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
About the gene
| Synonyms | SDH, SDH1 |
|---|---|
| Chromosome | 1: 17018722-17054032 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Oxidoreductase |
| Biological process | Electron transport, Host-virus interaction, Transport, Tricarboxylic acid cycle |
Function
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol- oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.