IFN-gamma Response
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 30 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 30 genes have a known function matching the annotation |
Why this annotation
STAT1 as master regulator, GBP1/GBP5 (IFN-γ-induced GTPases), CXCL9/CXCL10/CXCL11 triad (canonical IFN-γ chemokines), IDO1 (IFN-γ-induced immunosuppressive enzyme), TAP1/TAP2 (antigen processing), and CD40 collectively define a classical IFN-γ-activated macrophage program. Enrichment in mono_mac subset is consistent. Neighbor M8 confirms IFN-γ neighborhood; M44 captures the STAT1/chemokine/effector arm.
Genes
ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48, CTSH, CXCL10, CXCL11, CXCL9, DNASE2, GBP1, GBP5, IDO1, IL2RG, IL32, IL4I1, NUDT14, OPTN, PPP1R7, SDHB, SDHD, SOCS1, STAT1, TAP1, TAP2, TYMP, WARS1
Most correlated modules
- Immunoproteasome Induction · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.