CD48 — CD48 molecule
CD48 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD48's module in each cell type
About the gene
| Synonyms | BCM1, BLAST, hCD48, mCD48, SLAMF2 |
|---|---|
| Chromosome | 1: 160678746-160711831 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
Function
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK- cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.