ATP13A1 — ATPase 13A1
ATP13A1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP13A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell cAMP Signaling TCR Signaling | AP1G2, CCAR2, CDK9, CNOT3, GSR, LAX1, OFD1, PDE7A +3 more | |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, CD274, CD300LF, CD40, CD48, CTSH +21 more | View in SCUBA |
About the gene
| Synonyms | ATP13A, CGI-152, FLJ31858, KIAA1825 |
|---|---|
| Chromosome | 19: 19645198-19663676 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Protein transport, Transport |
Function
Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.