CD40 — CD40 molecule
CD40 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD40's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CXCL10, CXCL11, CXCL9 +18 more | View in SCUBA |
| Fibroblasts | NF-κB Inflammatory Activation Inflammatory | BIRC3, CTSS, DRAM1, HAPLN3, IL15RA, IL32, LAP3, STAT1 +5 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD48, CTSH +21 more | View in SCUBA |
| Monocytes | Tolerogenic Monocyte Activation Inflammatory | CCR5, CD80, GGT5, IDO1, IL4I1, MANF, PLA2G7, SLAMF7 +1 more | View in SCUBA |
About the gene
| Synonyms | Bp50, p50, TNFRSF5 |
|---|---|
| Chromosome | 20: 46118271-46129863 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.