CD300LF — CD300 molecule like family member f
CD300LF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD300LF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CDK2AP2, CEP83, COL4A4, DERL1 +29 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD40, CD48, CTSH +21 more | View in SCUBA |
| Monocytes | FPR1 Innate Sensing Innate immunity | FPR1, FYN, OSCAR, SELPLG, SIRPB1, SLC11A1, SULF2, SYTL1 +1 more | View in SCUBA |
About the gene
| Synonyms | CD300f, CLM1, IGSF13, IREM1, NKIR |
|---|---|
| Chromosome | 17: 74694311-74712978 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.