SEPTIN6 — Septin 6
SEPTIN6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEPTIN6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | RNA Processing Transport Housekeeping | BCL2, CDYL, CPSF6, DHX15, DHX9, EFR3A, EXOC1, FBXO38 +18 more | View in SCUBA |
| Natural Killer cells | Septin Cytoskeletal Assembly Cytoskeleton & motility | ALDOA, EEF1G, MIF, NME2, PLAAT3, POLD4, SEPTIN1, SEPTIN2 | View in SCUBA |
About the gene
| Synonyms | KIAA0128, MGC16619, MGC20339, SEP2, SEPT2, SEPT6 |
|---|---|
| Chromosome | X: 119615724-119693370 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Differentiation, Host-virus interaction, Spermatogenesis |
Function
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.