RNA Processing Transport
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include RNA helicases (DHX9, DHX15), nuclear import factors (IPO7, NUP153), RNA processing (CPSF6), cytoskeletal regulators (MAP4, SEPTIN6, ROCK2), and ubiquitin pathway components (USP10, RNF4, FBXO38). All genes show weak membership and coherence is unknown, indicating a loosely co-regulated module. The dominant theme is nuclear RNA processing and transport, with cytoskeletal and ubiquitin components as secondary features. Slight prolif_mac enrichment for UBAP2 and DHX15 is consistent with elevated RNA processing in proliferating cells. This module likely reflects general housekeeping RNA metabolism rather than a specific biological program.
Genes
BCL2, CDYL, CPSF6, DHX15, DHX9, EFR3A, EXOC1, FBXO38, GLYR1, GOLM2, GOLPH3, IPO7, MAP4, MDFIC, NAA35, NUP153, PPP3CB, PTPN11, RIF1, RNF4, ROCK2, SEPTIN6, SETD3, STAM2, UBAP2, UBP1, USP10
Most correlated modules
- RAB-mediated Trafficking · correlation 0.97
- Sphingolipid Membrane Homeostasis · correlation 0.96
- ER-Golgi Trafficking · correlation 0.96
- RNA Processing Housekeeping · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- ER-Golgi Trafficking · correlation 0.94
- Microtubule Organization · correlation 0.94
- Chromatin Regulatory Genes · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.