Mitochondrial Organization
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 30 genes have a known function matching the annotation |
Why this annotation
MIF (macrophage migration inhibitory factor) is the only core-membership hub gene — it is a pro-inflammatory cytokine and stress mediator. MICOS10/13 are mitochondrial inner membrane contact site components. ATP5MK/MJ are ATP synthase subunits. PHB1 is a mitochondrial chaperone. GABARAP links to autophagy. MACROH2A1, H3-3A, H2AZ2 are histone variants associated with chromatin remodeling and cellular senescence/stress. SEPTIN7 connects to cytoskeletal organization. The strong negative delta_inflammation (sig.) suggests this program is downregulated during gut inflammation. The combination of mitochondrial organization genes and MIF suggests a mitochondrial stress/homeostasis program.
Genes
ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G, FAM174C, GABARAP, H2AZ1, H2AZ2, H3-3A, MACROH2A1, MICOS10, MICOS13, MIF, MRPS24, NDUFA13, NME2, PHB1, POLR1H, PSMA6, RNASEK, SEPTIN6, SEPTIN7, TOMM5, TOMM6, TRAPPC5, UBE2V1
Most correlated modules
- Septin Cytoskeleton · correlation 0.97
- mRNA Translation · correlation 0.82
- NK Activating Receptors · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.