Septin Cytoskeletal Assembly
Gene co-expression module in Natural Killer cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
SEPTIN1, SEPTIN2, and SEPTIN6 are three members of the septin GTPase family, which form cytoskeletal filaments critical for NK cell lytic synapse formation and granule polarization. PLAAT3 is a phospholipase involved in membrane remodeling. NME2 is a nucleoside diphosphate kinase that supports GTP availability for GTPases. MIF is a pro-inflammatory cytokine/moonlighting enzyme. EEF1G is a translation elongation factor. ALDOA is glycolytic. The septin triad dominates and connects to neighbor M54 which contains actin regulators (SSH2) and granule exocytosis genes (SYTL3), together forming a cytoskeletal/cytotoxic program.
Genes
ALDOA, EEF1G, MIF, NME2, PLAAT3, POLD4, SEPTIN1, SEPTIN2, SEPTIN6
Most correlated modules
- Mitochondrial Membrane Organization · correlation 0.95
- Interferon NK Activation · correlation 0.88
- Housekeeping Mixed · correlation 0.80
- Histone Variant Remodeling · correlation 0.80
- Replication-Coupled Histones · correlation 0.66
- Inflammatory Stress Response · correlation 0.47
- NK Cytotoxic Signaling · correlation 0.39
- NK TGF-β Regulation · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.