SHROOM3 — Shroom family member 3
SHROOM3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHROOM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | KLF4 Terminal Differentiation Epithelial development | ECE1, KLF4, MARCHF3, MDK, RASSF6, SIK3, TRANK1, TRIM38 | View in SCUBA |
About the gene
| Synonyms | APXL3, KIAA1481, SHRM, ShrmL |
|---|---|
| Chromosome | 4: 76435229-76783253 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Developmental protein |
| Biological process | Cell shape |
Function
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.