MARCHF3 — Membrane associated ring-CH-type finger 3
MARCHF3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MARCHF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | KLF4 Terminal Differentiation Epithelial development | ECE1, KLF4, MDK, RASSF6, SHROOM3, SIK3, TRANK1, TRIM38 | View in SCUBA |
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tc17 / MAIT17 Tc17 program | AHR, BAIAP2, CA10, CCR9, GFPT2, HIC1, IL17A, IL2 +5 more | |
| Natural Killer cells | Housekeeping Mixed DNA regulation & transcription | ATP6V0C, ENSG00000285976, H2AJ, H3-3B, NCBP2AS2, PNPLA2, PRXL2C, TARS3 +1 more | View in SCUBA |
About the gene
| Synonyms | MARCH-III, MARCH3, MGC48332, RNF173 |
|---|---|
| Chromosome | 5: 126867714-127030558 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Transferase |
| Biological process | Endocytosis, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.