SIRPB1 — Signal regulatory protein beta 1
SIRPB1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIRPB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | FPR1 Innate Sensing Innate immunity | CD300LF, FPR1, FYN, OSCAR, SELPLG, SLC11A1, SULF2, SYTL1 +1 more | View in SCUBA |
About the gene
| Synonyms | CD172b, SIRP-BETA-1 |
|---|---|
| Chromosome | 20: 1561385-1620061 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.