SELPLG — Selectin P ligand

SELPLG belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SELPLG's module in each cell type

Cell type	Module	Shares the module with
Gamma-delta T cells	Effector Cell Migration migration & adhesion	ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11 +17 more
Macrophages	Innate Antiviral Sensing Innate immunity	ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more	View in SCUBA
Monocytes	FPR1 Innate Sensing Innate immunity	CD300LF, FPR1, FYN, OSCAR, SIRPB1, SLC11A1, SULF2, SYTL1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Lymphocyte Trafficking migration & adhesion	AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC +8 more
Natural Killer cells	NK Degranulation Activation activation	BIN2, CCND3, GPR141, OSBPL5, PXN, RASGRP2, SH3BP5, STING1 +3 more	View in SCUBA
Neutrophils	Mature Neutrophil Identity Developmental	JAML, LRP10, LRRK2, MME, MMP25, MSL1, R3HDM4, TLR8 +1 more

About the gene

Synonyms	CD162, PSGL-1
Chromosome	12: 108621895-108633894
Predicted location	Membrane
Essential gene	No
Protein class	Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted membrane proteins
Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Cell adhesion, Host-virus interaction

Function

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. (Microbial infection) Acts as a receptor for enterovirus 71

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.