SULF2 — Sulfatase 2
SULF2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SULF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt antimicrobial progenitor Antibacterial | CAMK1D, CHRM3, DIAPH2, EMP2, HES1, IFITM2, LYZ, PTPN13 | View in SCUBA |
| Fibroblasts | Activated Myofibroblast State Wound healing | BGN, BMP1, CPXM1, CTHRC1, EGFL6, FAP, KIAA0930, MASP1 +7 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Identity endothelial development | CHST12, ENDOD1, EPHB4, F2R, F8, GALNT1, KDR, NR2F2 +4 more | View in SCUBA |
| Monocytes | FPR1 Innate Sensing Innate immunity | CD300LF, FPR1, FYN, OSCAR, SELPLG, SIRPB1, SLC11A1, SYTL1 +1 more | View in SCUBA |
About the gene
| Synonyms | HSULF-2, KIAA1247, SULF-2 |
|---|---|
| Chromosome | 20: 47656197-47786616 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.