SYTL1 — Synaptotagmin like 1
SYTL1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYTL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell antigen presentation B cell maturation | APBB1IP, BMP2K, BTN2A2, CIITA, CYTH4, EVL, HHEX, MS4A1 +6 more | View in SCUBA |
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE +13 more | View in SCUBA |
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | ADGRG5, BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT +11 more | |
| Monocytes | FPR1 Innate Sensing Innate immunity | CD300LF, FPR1, FYN, OSCAR, SELPLG, SIRPB1, SLC11A1, SULF2 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more | |
| Natural Killer cells | NK Degranulation Activation activation | BIN2, CCND3, GPR141, OSBPL5, PXN, RASGRP2, SELPLG, SH3BP5 +3 more | View in SCUBA |
About the gene
| Synonyms | exophilin-7, FLJ14996, JFC1, SLP1 |
|---|---|
| Chromosome | 1: 27342020-27353937 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Exocytosis |
Function
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.